МОЛОДЁЖНЫЙ ПРОЕКТ ДЛЯ ТЕХ, КТО ДЕЛАЕТ ПЕРВЫЕ ШАГИ В НАУКЕ
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УСПЕХИ В НАУКАХ О ЧЕЛОВЕКЕ / ACHIEVEMENTS IN HUMAN SCIENCES / FORTSCHRITTE IN DEN HUMANWISSENSCHAFTEN
Ng Pui Yee, Irene Wong Chew Ling
Pathogenesis of Complications of Oocytes Donation (OD)
Ng Pui Yee, 6th year student at Medical Department of I.M. Sechenov Moscow State Medical University
ORCID ID https://orcid.org/0000-0002-3687-0708
E-mail: ng-pui-yee@j-spacetime.com; kellynpy94@gmail.com
Irene Wong Chew Ling, 6th year student at Medical Department of I.M. Sechenov Moscow State Medical University
ORCID ID https://orcid.org/0000-0002-4803-2824
E-mail: irene-wong-chew-ling@j-spacetime.com; irenewong@live.com.au
Oocyte donation (OD) is the process by which donated eggs are used to conceived in another woman with donor sperm or own husband’s sperm. OD makes it possible for subfertile women to conceive. OD is a specific method of artificial reproductive technology that is accompanied by higher risk of preeclampsia during pregnancy. Pregnancies achieved using OD with unrelat-ed donors are unique, since the entire fetal genome is allogeneic to the mother. The more antigenic dissimilarity, the more risk of maternal morbidity due to disturbance of immune tolerance which intervenes in modulating pregnancy related pathologies. Besides that, dysregulation of the local immune response at the fetal-maternal interface lead to higher incidence of placental pathological lesions, such as chronic villitis of unknown etiology, chronic deciduitis and massive chronic intervillositis in OD.
This paper is maternofetal immunological tolerance phenomenon studies review, and to characterize it and relate this phe-nomenon during pregnancies with a semiallogeneic fetus, and those with an allogeneic fetus in OD pregnancies we used source, phenomenological, problem and system analysis, classification and descriptive methods. Using these approaches we also addressed whether an inadequate maternal immunological response to the allogenic fetus could lead to a higher prevalence of preeclampsia in OD pregnancies.
We conclude that OD provides a valuable addition to the list of treatment options for women who require artificial reproduc-tive technology. The benefits of having a take-home baby are counter-balanced by the higher risk of maternal morbidity. The increased rate of complications may be related to the allogeneic nature of the fetus. Understanding the role of the immune system in successful OD pregnancies also has broader biomedical significance in that it may also give insight into immune mechanisms leading to immunologic tolerance for HLA mismatched solid organ transplants.
Keywords: oocyte donation; preeclampsia; chronic villitis of unknown etiology; chronic deciduitis and massive chronic intervillositis; immunological tolerance
Cite MLA 7:
Ng, P. Y., and I. Wong Chew Ling. "Pathogenesis of Complications of Oocytes Donation (OD)." Electronic Scientific Edition Almanac Space and Time15.1 (Studia Studiosorum: Achievements of Young Researchers) (2017). Web. <2227-9490e-aprovr_e-ast15-1.2017.26>.
Нг Пуи Йее, Ирене Вонг Чеу Линг
Патогенез осложнений донации ооцитов (ДО)
Нг Пуи Йее, студентка 6 курса лечебного факультета Первого Московского государственного медицинского университета им. И.М. Сеченова
ORCID ID https://orcid.org/0000-0002-3687-0708
E-mail: ng-pui-yee@j-spacetime.com; kellynpy94@gmail.com
Ирене Вонг Чеу Линг, студентка 6 курса лечебного факультета Первого Московского государственного медицинского университета им. И.М. Сеченова
ORCID ID https://orcid.org/0000-0002-4803-2824
E-mail: irene-wong-chew-ling@j-spacetime.com; irenewong@live.com.au
Донация ооцитов (ДО) — это процесс, с помощью которого женщине подсаживают бластоцисты, образованные из яйцеклетки другой женщины и донорской спермы или спермы собственного мужа. ДО предоставляет бесплодным женщинам возможность забеременеть. Это особый метод искусственных репродуктивных технологий, который имеет повышенный риск преэклампсии во время беременности. Беременность, достигнутая с использованием ДО с несвязанными донорами, уникальна, поскольку весь геном плода является аллогенным для матери. Чем больше антигенного несходства, тем больше риск развития осложненеий беременности из-за нарушения иммуннологической толерантности. Кроме того, дисрегуляция локального иммунного ответа может приводить и к плацентарной патологии, такой как хронический виллит, хронический децидиутик и массивный хронический интервиллозит. Цель этого обзора — охарактеризовать механизмы развития осложнений беременности при ДО.
Ключевые слова: донация ооцитов; преэклампсия; хронический виллит; хронический децидиутик; массивный хронический интервиллозит; иммуннологическая толерантность.
Цитирование по ГОСТ Р 7.0.11—2011:
Ng, P. Y., Wong Chew Ling, I. Pathogenesis of Complications of Oocytes Donation (OD) [= Патогенез осложнений донации ооцитов (ОД)] [Электронный ресурс] / Нг Пуи Йее, Ирене Вонг Чеу Линг // Электронное научное издание Альманах Пространство и Время. — 2017. — Т. 15. — Вып. 1: Studia studiosorum: успехи молодых исследователей. — Стационарный сетевой адрес: 2227-9490e-aprovr_e-ast15-1.2017.26.
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