МОЛОДЁЖНЫЙ ПРОЕКТ ДЛЯ ТЕХ, КТО ДЕЛАЕТ ПЕРВЫЕ ШАГИ В НАУКЕ
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ARBOR VITAE: ДРЕВО ЖИЗНИ/ ARBOR VITAE: TREE OF LIFE / ARBOR VITAE: BAUM DES LEBEN Школа научного мастерства: Первый МГМУ имени И.М. Сеченова / School of Scientific Excellence: Sechenov First Moscow State Medical University / Die Schule der wissenschaftlichen Meisterschaft: die Erste Moskauer staatliche medizinische I.M. Setschenow-Universität
DOI: 10.24411/2227-9490-2018-12073
Бекеев С.Ш., Алданов И.К., Доброхотов Д.А., Нестерова О.В.
Изучение возможности использования свежих корневищ и листьев Ириса германского для получения гомеопатических препаратов
Бекеев Саид Шамилевич, студент Ресурсного центра «Медицинский Сеченовский Предуниверсарий» ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» Минздрава России (Сеченовский университет)
ORCID ID https://orcid.org/0000-0002-1841-4653
E-mail: said-sh-bekeev@j-spacetime.com; saidov008@mail.ru
Алданов Исламудин Казакбиевич, студент Ресурсного центра «Медицинский Сеченовский Предуниверсарий» ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» Минздрава России (Сеченовский университет)
ORCID ID https://orcid.org/0000-0002-8859-3124
E-mail: islamudin-k-aldanov@j-spacetime.com; aldanov0405002@mail.ru
Доброхотов Денис Анатольевич, кандидат фармацевтических наук, доцент кафедры химии Института фармации ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» Минздрава России (Сеченовский университет)
ORCID ID https://orcid.org/0000-0002-6069-4978
E-mail: denis-a-dobrokhotov@j-spacetime.com; dennicas@mail.ru
Нестерова Ольга Владимировна, доктор фармацевтических наук, профессор кафедры химии Института фармации, заведующая кафедрой химии Института фармации ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» Минздрава России (Сеченовский университет)
ORCID ID https://orcid.org/0000-0002-7424-0627
E-mail: olga-v-nesterova@j-spacetime.com; olganesterova9297@mail.ru
Несмотря на то, что корневища ириса германского входят в списки фармакопейных сырья многих стран, в РФ данное перспективное сырье не является официально признанным, что обуславливает актуальность исследований, направленных на изучение показателей качества данного сырья. Для расширения сырьевой базы были изучены также листья ириса германского. Для каждого из двух видов свежего сырья — корневищ и листьев ириса германского — были проведены качественные реакции на основные группы биологически активных веществ, результаты которых позволили обосновать возможность получения на основе обоих видов сырья настоек матричных гомеопатических.
Ключевые слова: касатик; Ирис германский; корневища; листья; матричная гомеопатическая настойка; стандартизация; фармакопея; качественный анализ.
Цитирование по ГОСТ Р 7.0.11—2011:
Бекеев, С. Ш., Алданов, И. К., Доброхотов, Д. А., Нестерова, О. В. Изучение возможности использования свежих корневищ и листьев Ириса германского для получения гомеопатических препаратов [Электронный ресурс] / С.Ш. Бекеев, И.К. Алданов, Д.А. Доброхотов, О.В. Нестерова // Электронное научное издание Альманах Пространство и Время. — 2018. — Т. 16. — Вып. 3—4. DOI: 10.24411/2227-9490-2018-12073. Стационарный сетевой адрес: 2227-9490e-aprovr_e-ast16-3_4.2018.073.
DOI: 10.24411/2227-9490-2018-12073
Bekeev S.Sh., Aldanov I.K., Dobrokhotov D.A., Nesterova O.V. Studying Possibility of Using Fresh Rhizomes and Leaves of German Iris for Producing Homeopathic Medicines
Said Sh. Bekeev, student at the Medical Sechenov Pre-university Resource Center, Sechenov First Moscow State Medical University
ORCID ID https://orcid.org/0000-0002-1841-4653
E-mail: said-sh-bekeev@j-spacetime.com; saidov008@mail.ru
Islamudin K. Aldanov, student at the Medical Sechenov Pre-university Resource Center, Sechenov First Moscow State Medical University
ORCID ID https://orcid.org/0000-0002-8859-3124
E-mail: islamudin-k-aldanov@j-spacetime.com; aldanov0405002@mail.ru
Denis A. Dobrokhotov, Ph.D. (Pharmacy), Associate Professor at the Chair of Chemistry, Sechenov First Moscow State Medical University, Institute of Pharmacy
ORCID ID https://orcid.org/0000-0002-6069-4978
E-mail: denis-a-dobrokhotov@j-spacetime.com; dennicas@mail.ru
Olga V. Nesterova, Doctor of Pharmacy, Professor, Head of the Chair of Chemistry, Sechenov First Moscow State Medical University, Institute of Pharmacy
ORCID ID https://orcid.org/0000-0002-7424-0627
E-mail: olga-v-nesterova@j-spacetime.com; olganesterova9297@mail.ru
Plant products expansion is one of the urgent problems of modern pharmacology and health care in general. Types of plant raw materials used in medicine for many centuries, but undeservedly forgotten hold a special place here. A special place here belongs to the. Such raw material is the iris root used in Western European and Russian medical practices. Currently, this raw material is not a pharmacopoeial in the Russian Federation; however, it is included in a number of leading foreign pharmacopoeias. So, in particular, despite the status of rhizomes of German iris (Iris germanica L.) as a pharmacopoeial raw material in Pharmacopée française, 10ème éd. (1982), British Herbal Pharmacopoeia, 3rd and 4th eds. (1991, 1996) and British Pharmacopoeia 2008 (2007), Indian Pharmacopoeia (1996), Pharmacopoeia of the People's Republic of China (2005), European Pharmacopoeia, 6th ed. (2007), American Herbal Pharmacopoeia (2008), Deutsches Arzneibuch 2008 (2008), and Japanese Pharmacopoeia, 15th ed. (2009), in the Russian Federation, this promising raw material is not officially recognized. This determined our choice of the pharmacognostic analysis and macrodiagnostic indicators of rhizomes and leaves of Iris germanica L. as research subject.
In the theoretical part of our research, our source analysis (as a part of pharmacognostic analysis) revealed a significant biological activity of German iris organs and dosage forms from it, such as: immunomodulatory (in experiment), hypolipidemic, antiulcer, anti-inflammatory, antioxidant, inhibition of cytochrome P 450 1A activity, cytotoxic activity against Ehrlich ascites carcinoma cells, activity against cell line A2780 and K652, activity against SW48 cells (extract of the underground part of Germanic iris also prevents the migration of HeLa cells), antibacterial and antifungal activity of extracts of the underground part, antimalarial, phytotoxic activity of petroleum-ether extract of the underground part, and molluscicidal activity of the chlorophoric extract of the underground part.
In the practical part of our research, we planted a part of the studied rhizomes of the German Iris in the ground, where they remained until the formation of the developed aerial part. This part we also used in research for the production of raw materials "Leaves of German Iris". We carried out (a) a visual observation, and we described the results of which (morphological features of studied raw materials) in accordance with the requirements of the State Pharmacopoeia of the Russian Federation, the 13th edition (2005); (b) determination of the preliminary qualitative composition of both rhizomes and leaves, for which we performed qualitative reactions traditionally used to identify biologically active substances of different groups.
The results of qualitative reactions for determining various groups of biologically active substances contained in the aqueous extraction and in matrix homeopathic tincture from both rhizomes and leaves of German Iris were identical for both types of these raw materials.
This allowed us to conclude that it is possible to obtain matrix homeopathic tinctures on the basis of both rhizomes and leaves of Germanic iris. Moreover, although the current state of the material base of science is not able to give an unequivocal answer about the possibilities of homeopathy, we are of the opinion that homeopathy is an effective method of obtaining drugs based on medicinal plant materials. Therefore, we also believe that further standardization studies for introducing rhizomes and leaves of Iris germanica L. into the pharmacopoeial nomenclature are extremely important.
Keywords: Iridaceae; Iris germanica L.; rhizomes; leaves; matrix homeopathic tincture; standardization; pharmacopoeia; qualitative analysis.
Cite MLA 7:
Bekeev, S. Sh., I. K. Aldanov, D. A. Dobrokhotov, and O. V. Nesterova. "Studying Possibility of Using Fresh Rhizomes and Leaves of German Iris for Producing Homeopathic Medicines." Electronic Scientific Edition Almanac Space and Time 16.3—4 (2018). DOI: 10.24411/2227-9490-2018-12073. Web. <2227-9490e-aprovr_e-ast16-3_4.2018.073>. (In Russian).
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